{"id":1000,"date":"2018-01-21T17:35:29","date_gmt":"2018-01-21T16:35:29","guid":{"rendered":"http:\/\/klubcf.sk\/?p=1000"},"modified":"2018-01-21T17:53:11","modified_gmt":"2018-01-21T16:53:11","slug":"informacna-grafika-triedy-mutacii-proteinu-cftr","status":"publish","type":"post","link":"https:\/\/klubcf.sk\/index.php\/2018\/01\/21\/informacna-grafika-triedy-mutacii-proteinu-cftr\/","title":{"rendered":"INFORMA\u010cN\u00c1 GRAFIKA &#8211; Triedy Mut\u00e1ci\u00ed Prote\u00ednu CFTR"},"content":{"rendered":"<p><strong> &nbsp; &nbsp; &nbsp; &nbsp;<\/strong><strong>Informa\u010dn\u00fd obr\u00e1zok<\/strong>, kde si m\u00f4\u017eete pozrie\u0165&nbsp;<strong>triedy mut\u00e1ci\u00ed prote\u00ednu CFTR.<\/strong><\/p>\n<p>Ak\u00e1 chyba prote\u00ednu CFTR vlastne nast\u00e1va v jednotliv\u00fdch pr\u00edpadoch a ktor\u00e9 lieky bud\u00fa sl\u00fa\u017ei\u0165 na n\u00e1pravu.<\/p>\n<p>Dop\u013a\u0148a&nbsp;predch\u00e1dzaj\u00faci \u010dl\u00e1nok, kde sme predstavili v\u00fdvoj liekov a lie\u010dby vo svete<br \/>\n<em>(odkaz na \u010dl\u00e1nok:&nbsp;<a href=\"http:\/\/klubcf.sk\/index.php\/2018\/01\/02\/prehlad-prebiehajuceho-vyskumu-liekov\/\">http:\/\/klubcf.sk\/index.php\/2018\/01\/02\/prehlad-prebiehajuceho-vyskumu-liekov\/<\/a>).<\/em><\/p>\n<p>Prote\u00edn CFTR pri spr\u00e1vnej funkcii umo\u017e\u0148uje prestup chloridov, sol\u00ed, vody cez chloridov\u00fd kan\u00e1l na povrchu bunky.<\/p>\n<p>Pri mut\u00e1cii \/ nespr\u00e1vnej funkcii sa spr\u00e1va nasledovne:<\/p>\n<ul>\n<li>Trieda I: Funk\u010dn\u00fd prote\u00edn CFTR sa nevytvor\u00ed.<\/li>\n<li>Trieda II: Prote\u00edn CFTR sa vytvor\u00ed, je ale zlo\u017een\u00fd nespr\u00e1vne a nedostane sa na povrch bunky.<\/li>\n<li>Trieda III: CFTR prote\u00edn sa vytvor\u00ed a dosiahne povrch bunky, nefunguje v\u0161ak jeho aktiv\u00e1cia a regul\u00e1cia na povrchu bunky.<\/li>\n<li>Trieda IV: CFTR prote\u00edn sa vytvor\u00ed a dosiahne povrch bunky, priestupnos\u0165 chloridov je v\u0161ak zn\u00ed\u017een\u00e1.<\/li>\n<li>Trieda V: Prote\u00edn CFTR sa tvor\u00ed v nedostato\u010dnom mno\u017estve.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-1001\" src=\"http:\/\/klubcf.sk\/wp-content\/uploads\/2018\/01\/INFO-GRAFIKA-TRIEDY-MUTACII-1024x971.jpg\" alt=\"\" width=\"1024\" height=\"971\" srcset=\"https:\/\/klubcf.sk\/wp-content\/uploads\/2018\/01\/INFO-GRAFIKA-TRIEDY-MUTACII-1024x971.jpg 1024w, https:\/\/klubcf.sk\/wp-content\/uploads\/2018\/01\/INFO-GRAFIKA-TRIEDY-MUTACII-300x285.jpg 300w, https:\/\/klubcf.sk\/wp-content\/uploads\/2018\/01\/INFO-GRAFIKA-TRIEDY-MUTACII-768x729.jpg 768w, https:\/\/klubcf.sk\/wp-content\/uploads\/2018\/01\/INFO-GRAFIKA-TRIEDY-MUTACII.jpg 1324w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; &nbsp; &nbsp;Informa\u010dn\u00fd obr\u00e1zok, kde si m\u00f4\u017eete pozrie\u0165&nbsp;triedy mut\u00e1ci\u00ed prote\u00ednu CFTR. Ak\u00e1 chyba prote\u00ednu CFTR vlastne nast\u00e1va v jednotliv\u00fdch pr\u00edpadoch a ktor\u00e9 lieky bud\u00fa sl\u00fa\u017ei\u0165 na n\u00e1pravu. Dop\u013a\u0148a&nbsp;predch\u00e1dzaj\u00faci \u010dl\u00e1nok, kde sme predstavili v\u00fdvoj liekov a lie\u010dby vo svete (odkaz na \u010dl\u00e1nok:&nbsp;http:\/\/klubcf.sk\/index.php\/2018\/01\/02\/prehlad-prebiehajuceho-vyskumu-liekov\/). Prote\u00edn CFTR pri spr\u00e1vnej funkcii umo\u017e\u0148uje prestup chloridov, sol\u00ed, vody cez chloridov\u00fd kan\u00e1l [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[10],"tags":[],"class_list":["post-1000","post","type-post","status-publish","format-standard","hentry","category-vyskum-a-vyvoj"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>INFORMA\u010cN\u00c1 GRAFIKA - Triedy Mut\u00e1ci\u00ed Prote\u00ednu CFTR - klubcf.sk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/klubcf.sk\/index.php\/2018\/01\/21\/informacna-grafika-triedy-mutacii-proteinu-cftr\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"INFORMA\u010cN\u00c1 GRAFIKA - Triedy Mut\u00e1ci\u00ed Prote\u00ednu CFTR - klubcf.sk\" \/>\n<meta property=\"og:description\" content=\"&nbsp; &nbsp; &nbsp; &nbsp;Informa\u010dn\u00fd obr\u00e1zok, kde si m\u00f4\u017eete pozrie\u0165&nbsp;triedy mut\u00e1ci\u00ed prote\u00ednu CFTR. Ak\u00e1 chyba prote\u00ednu CFTR vlastne nast\u00e1va v jednotliv\u00fdch pr\u00edpadoch a ktor\u00e9 lieky bud\u00fa sl\u00fa\u017ei\u0165 na n\u00e1pravu. Dop\u013a\u0148a&nbsp;predch\u00e1dzaj\u00faci \u010dl\u00e1nok, kde sme predstavili v\u00fdvoj liekov a lie\u010dby vo svete (odkaz na \u010dl\u00e1nok:&nbsp;http:\/\/klubcf.sk\/index.php\/2018\/01\/02\/prehlad-prebiehajuceho-vyskumu-liekov\/). Prote\u00edn CFTR pri spr\u00e1vnej funkcii umo\u017e\u0148uje prestup chloridov, sol\u00ed, vody cez chloridov\u00fd kan\u00e1l [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/klubcf.sk\/index.php\/2018\/01\/21\/informacna-grafika-triedy-mutacii-proteinu-cftr\/\" \/>\n<meta property=\"og:site_name\" content=\"klubcf.sk\" \/>\n<meta property=\"article:published_time\" content=\"2018-01-21T16:35:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-01-21T16:53:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/klubcf.sk\/wp-content\/uploads\/2018\/01\/INFO-GRAFIKA-TRIEDY-MUTACII.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1324\" \/>\n\t<meta property=\"og:image:height\" content=\"1256\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"klubcf123\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Autor\" \/>\n\t<meta name=\"twitter:data1\" content=\"klubcf123\" \/>\n\t<meta name=\"twitter:label2\" content=\"Predpokladan\u00fd \u010das \u010d\u00edtania\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 min\u00fata\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/klubcf.sk\/index.php\/2018\/01\/21\/informacna-grafika-triedy-mutacii-proteinu-cftr\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/klubcf.sk\/index.php\/2018\/01\/21\/informacna-grafika-triedy-mutacii-proteinu-cftr\/\"},\"author\":{\"name\":\"klubcf123\",\"@id\":\"https:\/\/klubcf.sk\/#\/schema\/person\/152c665d546b6961e696b60f88215719\"},\"headline\":\"INFORMA\u010cN\u00c1 GRAFIKA &#8211; 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Ak\u00e1 chyba prote\u00ednu CFTR vlastne nast\u00e1va v jednotliv\u00fdch pr\u00edpadoch a ktor\u00e9 lieky bud\u00fa sl\u00fa\u017ei\u0165 na n\u00e1pravu. Dop\u013a\u0148a&nbsp;predch\u00e1dzaj\u00faci \u010dl\u00e1nok, kde sme predstavili v\u00fdvoj liekov a lie\u010dby vo svete (odkaz na \u010dl\u00e1nok:&nbsp;http:\/\/klubcf.sk\/index.php\/2018\/01\/02\/prehlad-prebiehajuceho-vyskumu-liekov\/). 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